Giving female mice a certain drug (rapamycin) once a week helps them run more on their own compared to giving it more often or not at all.

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin

Randomized Controlled Trial

Animal

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Source Study

Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin

Score: 9

DOI: 10.1101/2025.03.10.642477

Similar Assertions

In female mice that exercised a lot for 8 weeks, taking rapamycin — a drug that affects aging — either once a week or three times a week didn’t stop them from getting stronger or improving their stamina.

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In female mice that run a lot, taking rapamycin frequently stops them from losing fat — even though exercise usually helps them slim down.

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Female mice on a weekly rapamycin dose ran more and faster than those on a more frequent dose or no drug, but despite running more, they didn’t lose more fat or get healthier metabolically.

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Even when taking rapamycin, female mice still get stronger and fitter from using a weighted exercise wheel — the drug doesn't stop their workout gains.

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In female mice that run with added weight, giving rapamycin three times a week blocks a key muscle growth signal, but giving it just once a week doesn’t keep that block going — so how often you dose matters.

87%