Mice with extra kidney lymphatic vessels had less of two key proteins that reabsorb salt in the kidneys, helping them excrete more salt.
Scientific Claim
In mice with hypertension, kidney-specific lymphangiogenesis was associated with reduced renal abundance of total NCC and cleaved ENaCα proteins (n=3-4 mice per group for protein analysis).
Original Statement
“We observed a significant reduction in the abundance of cl-ENaCα (Fig. 1i and j), suggesting reduced ENaC-dependent Na+ reabsorption in KidVD+ mice... a significant reduction in total NCC and cl-ENaCα in KidVD+ mice (Fig. 4h and i).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'associated with' and includes sample size data, which is appropriate for this animal study design that cannot establish causation.
Evidence from Studies
Supporting (1)
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.