quantitative
Analysis v1
16
0
Mice with extra kidney lymphatic vessels on a hypertension-inducing drug excreted more sodium relative to their kidney function compared to normal mice.
Scientific Claim
In mice with l-NAME-induced hypertension, kidney-specific VEGF-D overexpression was associated with increased urinary fractional excretion of sodium (n=5-6 per group).
Original Statement
“Urinary fractional excretion of Na+ was also significantly increased in KidVD+ mice (Fig. 1f) with equivalent ClCr between groups (Fig. 1g).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'associated with' and includes sample size data, which is appropriate for this animal study design that cannot establish causation.
Evidence from Studies
Supporting (1)
16
16
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.
Randomized Controlled Trial
Animal
2020 MayContradicting (0)
0
No contradicting evidence found