mechanistic
Analysis v1
Strong Support
In mice with fatty liver, certain proteins and their genetic instructions are lower in the liver's waste-processing units, which might mean those units aren't working as well as they should.
10
0
Evidence from Studies
Supporting (1)
10
Community contributions welcome
10
Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis.
Cross-Sectional Study
Animal
2016 Jan 22The study found that in mice with fatty livers, the proteins and genes needed to make lysosomes acidic were lower, which matches the claim.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.