Mice with high blood pressure given PRO20 were able to excrete salt normally after a salt load, unlike untreated mice.

Scientific Claim

PRO20 treatment was associated with sodium excretion levels similar to sham controls at 1 and 3 hours post-saline challenge in 2K1C Goldblatt mice.

Original Statement

“Mice subjected to 2K1C + PRO20 did not show Na+ retention (red line and squares).”

From study:(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design is observational, so 'associated with' correctly reflects the relationship without implying causation.

Evidence from Studies

Supporting (1)

(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Randomized Controlled Trial

Animal

2025 Apr 28

Contradicting (0)

No contradicting evidence found

Source Study

(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Score: 11

DOI: 10.3390/ijms26094177