Blocking kidney receptor stops high blood pressure in mice
(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
PRO20 reduced Ang II without affecting ACE activity
Typically, higher ACE activity means more Ang II, but PRO20 blocked Ang II despite unchanged ACE levels
Practical Takeaways
Monitor kidney health for blood pressure control by reducing processed foods high in sodium
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
PRO20 reduced Ang II without affecting ACE activity
Typically, higher ACE activity means more Ang II, but PRO20 blocked Ang II despite unchanged ACE levels
Practical Takeaways
Monitor kidney health for blood pressure control by reducing processed foods high in sodium
Publication
Journal
International Journal of Molecular Sciences
Year
2025
Authors
Pilar Cárdenas, Catalina Cid-Salinas, Allison C. León, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Rodrigo Yokota, Zoe Vallotton, D. Casarini, Minolfa C. Prieto, Ramón A. Lorca, Alexis A Gonzalez
Related Content
Claims (6)
Sodium intake increases plasma volume through osmotic water retention, leading to higher blood pressure due to increased fluid in a closed circulatory system.
In mice with a specific type of high blood pressure model, the PRR protein in the kidneys was 4 times higher in the clipped kidney and 2 times higher in the other kidney compared to healthy mice.
In mice with high blood pressure, the sodium channel protein in the kidneys was more than double in both kidneys, but a drug called PRO20 reduced this increase to about 1.5 times and 1.2 times in the clipped and other kidney.
When given PRO20, mice with high blood pressure didn't show higher levels of a key blood pressure hormone in the non-clipped kidney.
Mice with high blood pressure given PRO20 were able to excrete salt normally after a salt load, unlike untreated mice.