In mice with a specific type of high blood pressure model, the PRR protein in the kidneys was 4 times higher in the clipped kidney and 2 times higher in the other kidney compared to healthy mice.

Scientific Claim

In 2K1C Goldblatt mice, renal PRR protein expression increased 4.1-fold in clipped kidneys and 2.3-fold in non-clipped kidneys compared to sham controls.

Original Statement

“Protein levels of the PRR were augmented in left kidneys (fold change in control sham: 4.1 ± 0.2 vs. 1.0 ± 0.1, p < 0.001) and around two-fold in right kidneys (fold change in control [sham]: 2.3 ± 0.2 vs. 1.0 ± 0.1, p < 0.05).”

From study:(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The claim describes an observed measurement without implying causation, which is appropriate for a descriptive finding in an observational study.

Evidence from Studies

Supporting (1)

(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Randomized Controlled Trial

Animal

2025 Apr 28

Contradicting (0)

No contradicting evidence found

Source Study

(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Score: 11

DOI: 10.3390/ijms26094177

Similar Assertions

In mice with high blood pressure, the sodium channel protein in the kidneys was more than double in both kidneys, but a drug called PRO20 reduced this increase to about 1.5 times and 1.2 times in the clipped and other kidney.

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