When given PRO20, mice with high blood pressure didn't show higher levels of a key blood pressure hormone in the non-clipped kidney.

Scientific Claim

PRO20 treatment was associated with no increase in intrarenal Ang II levels in non-clipped kidneys of 2K1C Goldblatt mice.

Original Statement

“In the right kidneys of 2K1C + PRO20, augmentation of Ang II levels was completely prevented.”

From study:(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design cannot establish causation, so 'associated with' is appropriate for describing the observed relationship.

Evidence from Studies

Supporting (1)

(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Randomized Controlled Trial

Animal

2025 Apr 28

Contradicting (0)

No contradicting evidence found

Source Study

(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice

Score: 11

DOI: 10.3390/ijms26094177

Similar Assertions

The enzyme that makes blood pressure hormones increased in both kidneys of mice with high blood pressure, and PRO20 didn't stop this increase.

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