The enzyme that makes blood pressure hormones increased in both kidneys of mice with high blood pressure, and PRO20 didn't stop this increase.
Scientific Claim
Intrarenal ACE activity increased in both clipped and non-clipped kidneys of 2K1C Goldblatt mice, and PRO20 treatment was not associated with changes in this increase.
Original Statement
“Intrarenal ACE activity was increased in the left (Figure 3A) and right (Figure 3B) kidneys from 2K1C mice subjected to 7 days of left renal arterial clipping. Infusion of PRO20 in 2K1C mice did not alter this effect.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim describes observed measurements without causal implications, which is appropriate for a descriptive finding in an observational study.
Evidence from Studies
Supporting (1)
(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice