The Claim
Red wine grape pomace supplementation significantly reduced intestinal permeability in SR-B1−/−ApoE-R61h/h mice with diet-induced ischemic heart disease, as evidenced by a decrease in plasma FITC-dextran levels from 29.71 to 9.49 µg/mL and plasma LPS from 1.09 to 0.56 EU/mL.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In mice with a genetic form of ischemic heart disease and a compromised gut barrier, supplementation with red wine grape pomace lowered markers of intestinal leakage, including plasma FITC-dextran and LPS, indicating a tighter gut barrier.
See the scientific wording
Red wine grape pomace supplementation significantly reduced intestinal permeability in SR-B1−/−ApoE-R61h/h mice with diet-induced ischemic heart disease, lowering plasma FITC-dextran levels from 29.71 to 9.49 µg/mL and plasma LPS from 1.09 to 0.56 EU/mL, indicating improved gut barrier integrity.
Undigested compounds from grape pomace reach the colon, where gut bacteria break them down into substances that strengthen the glue between gut lining cells. This prevents harmful substances from leaking into the blood, which lowers inflammation and improves heart health.
What the research says
1 studyMice with serious heart problems were fed a supplement made from crushed grape skins and seeds, and their leaky guts got better—less stuff from their intestines leaked into their blood.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.