When mice can't use vitamin D properly, their bodies overreact to bacterial toxins, causing dangerous inflammation and higher death rates—meaning vitamin D helps calm down harmful immune responses.

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Pro

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Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155–SOCS1 in Macrophages

Case-Control Study

Animal

2013 Apr 1

When mice don’t have a working vitamin D system, their bodies overreact to bacteria, making too many dangerous inflammation chemicals and sometimes dying. This study shows vitamin D normally acts like a brake to calm down that overreaction.

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No contradicting evidence found

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Source Study

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155–SOCS1 in Macrophages

Score: 12

DOI: 10.4049/jimmunol.1203273

Similar Assertions

When your body uses vitamin D properly, it helps calm down your immune system by turning off genes that cause inflammation, which can make you feel less swollen or sore.

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Vitamin D and vitamin A work together like a team to help your body calm down inflammation and fight off germs better than either one could alone.

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