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Claim
Strong Support
correlational
Analysis v4

Rhesus monkeys that ate 30% fewer calories than normal, starting between ages 7 and 14 and continuing for more than 20 years, died from age-related causes at 2.9 times lower rates and from any cause...

19
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

Eating less food slows down the body’s energy use, which reduces damage to cells and turns on repair systems. This keeps organs and tissues working properly for longer, preventing the diseases that usually kill older animals.

Most probable mechanism

In Simple Terms

Eating less food lowers the amount of energy the body processes, which reduces wear and tear on cells and allows the body to focus on repairing damage instead of growing and storing energy. This keeps cells healthier for longer and prevents the buildup of problems that cause aging and death.

Causal chain
1

Caloric restriction reduces mitochondrial electron transport chain activity and lowers reactive oxygen species production in tissues

Supported by evidence
which leads to
2

Reduced metabolic flux activates nutrient-sensing pathways that increase autophagy and proteostasis

Supported by evidence
which leads to
3

Enhanced cellular cleanup removes damaged proteins, organelles, and macromolecules that accumulate with age

Supported by evidence
which leads to
4

Suppressed accumulation of molecular damage preserves tissue function and delays onset of age-related pathologies

Supported by evidence
which leads to
5

Delayed tissue dysfunction reduces incidence of fatal age-related diseases such as cancer, cardiovascular degeneration, and neurodegeneration

Supported by evidence

Evidence from Studies

Supporting (1)

19

Community contributions welcome

19

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Cohort Study
Animal
2014 Apr 1

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Score: 19
DOI: 10.1038/ncomms4557

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In rhesus monkeys, reducing calorie intake lowers death rates from aging and increases lifespan, showing that how diet affects aging is similar in primates and other animals with shorter lives.

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Rhesus monkeys fed a reduced-calorie diet lived longer than the typical lifespan of 26 years seen in monkeys fed normally at the same research center.

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In rhesus monkeys, a diet with fewer calories does not raise the likelihood of dying from causes unrelated to aging, because the rate of such deaths relative to total lifespan is the same as in monkeys eating normally.

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Monkeys that eat fewer calories over many years stay more active as they age, while monkeys that eat normally become much less active over time.

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Male grey mouse lemurs that eat 30% fewer calories starting in early adulthood live 50% longer on average and die less frequently from age-related causes compared to those eating normally.

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