Most people with untreated Graves' disease have certain immune proteins in their blood that can affect the thyroid, but not everyone has them.

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Pro

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Against

Evidence from Studies

Supporting (1)

32

Community contributions welcome

32

Correlation between thyrotropin-displacing activity and human thyroid-stimulating activity by immunoglobulins from patients with Graves' disease and other thyroid disorders.

Cross-Sectional Study

Human

1979 Mar

The study looked at blood from people with Graves’ disease and found that 70.4% had one type of abnormal antibody and 81.5% had another, just like the claim says. So, the study supports the claim.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Correlation between thyrotropin-displacing activity and human thyroid-stimulating activity by immunoglobulins from patients with Graves' disease and other thyroid disorders.

Score: 32

DOI: 10.1210/JCEM-48-3-398

Similar Assertions

In people with Graves’ disease, a blood marker called TDA doesn’t seem to predict how much their thyroid is being stimulated — even when they’re not on treatment or when they’re in remission.

32

0

90%

In people with an overactive thyroid caused by Graves’ disease, a certain blood signal called hTSA shows up more often than another one called TDA, which might mean it's a better clue for doctors to spot the disease.

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Some people with certain types of thyroid inflammation (like Hashimoto's or subacute thyroiditis) can have a substance called TDA in their blood, but it doesn't actually turn on the thyroid like it does in Graves’ disease — so TDA might not mean the thyroid is being overstimulated.

32

0

85%

When someone has Graves’ disease, their thyroid hormones get too high, which tells the brain to stop making a hormone that stimulates the thyroid — so that hormone ends up being very low or even missing in blood tests.

38

0

72%

If someone has an underactive thyroid and signs of an overactive immune system — especially bulging eyes — doctors should still think about Graves’ disease, even if the thyroid isn’t overactive.

20

0

70%