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assertion
Analysis v1
Strong Support

A different molecule called MOTS-c helps the body use sugar better by turning on a cellular energy switch called AMPK.

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Evidence from Studies

Supporting (1)

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial
Animal
2015 Mar 3

This study found that a tiny molecule from mitochondria, called MOTS-c, helps cells take in sugar better and stay healthy without needing growth hormone — it works by turning on a cellular energy sensor called AMPK.

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No contradicting evidence found

Similar Assertions

MOTS-c reduces visceral and hepatic fat and improves insulin sensitivity even on a high-fat diet by activating AMPK, the cellular energy sensor, which enhances glucose uptake, insulin signaling, and fuel efficiency.

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MOTS-c made muscle cells produce more GLUT4 (a sugar transporter) and turned on AMPK (an energy sensor), two key players in how muscles use sugar.

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