A different molecule called MOTS-c helps the body use sugar better by turning on a cellular energy switch called AMPK.
Scientific Claim
MOTS-c activates AMP-activated protein kinase (AMPK), leading to improved glucose uptake, insulin sensitivity, and metabolic efficiency independent of growth hormone signaling.
Original Statement
“MOTS-c reduced visceral fat, reduced liver fat, and improved insulin sensitivity even on a poor diet. But the mechanism was different. Instead of stimulating growth hormone pathways, MOTS-c activated AMPK, which is the cell's energy sensor. So improving glucose uptake, insulin signaling, and fuel efficiency.”
Context Details
Domain
pharmacology
Population
animal
Subject
MOTS-c
Action
activates
Target
AMP-activated protein kinase (AMPK)
Intervention Details
Evidence from Studies
Supporting (1)
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
This study found that a tiny molecule from mitochondria, called MOTS-c, helps cells take in sugar better and stay healthy without needing growth hormone — it works by turning on a cellular energy sensor called AMPK.