MOTS-c treatment made the diabetic rats' heart cells have more mitochondria, which are the energy factories of cells.
Scientific Claim
MOTS-c treatment (15 mg/kg/day for 3 weeks) in diabetic rats was associated with increased citrate synthase activity compared to untreated diabetic rats and controls.
Original Statement
“The activity of CS normalised to protein content was significantly higher in the MOTS-c-treated diabetic group than in the control and untreated diabetic groups, indicating that the MOTS-c-treated group had increased mitochondrial content (Figure 2G).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports association claims. 'Was associated with' correctly reflects the evidence without implying causation.
Evidence from Studies
Supporting (1)
Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart