mechanistic
Analysis v1
16
0
Mouse pigment cells that make Oca2 protein can turn back into stem cells after moving to the bulge area of the hair follicle.
Scientific Claim
Oca2-expressing melanocyte stem cells in mice are associated with dedifferentiation into undifferentiated states upon migration to the bulge compartment.
Original Statement
“Oca2+ McSCs in the HG but not mature bulb melanocytes can dedifferentiate to give rise to undifferentiated McSCs in the niche.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Uses 'associated with' and specifies the cell type (Oca2-expressing) and location (bulge compartment), avoiding causal language.
Evidence from Studies
Supporting (1)
16
16
Dedifferentiation maintains melanocyte stem cells in a dynamic niche
Cohort Study
Animal
2023 AprContradicting (0)
0
No contradicting evidence found