When your muscles store glycogen, it holds onto water—about 3 to 4 grams of water for every gram of glycogen. If glycogen runs low, cells get less hydrated, and that makes creatine less effective at...
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Evidence from Studies
Supporting (1)
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Relationship between muscle water and glycogen recovery after prolonged exercise in the heat in humans
Cross-Sectional Study
Human
2015 SepContradicting (2)
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Muscle glycogen depletion does not alter segmental extracellular and intracellular water distribution measured using bioimpedance spectroscopy.
Randomized Controlled Trial
Human
2018 Jun 1Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.