The Claim

Resistance training induces skeletal muscle hypertrophy through mTORC1-independent pathways, including MAPK signaling, YAP activation, and TRIM28 phosphorylation, which regulate transcription and ribosome biogenesis independently of the mTORC1 pathway.

Source: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.

What the research says

Not yet evaluated

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Supports
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Challenges
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These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
0 studies reviewed
In plain English

When you lift weights, your muscles grow bigger not just through the usual pathway scientists know about, but also through other hidden backup systems in your cells that turn on genes and make more protein factories—all without needing the main growth switch.

See the scientific wording

Resistance training induces skeletal muscle hypertrophy through mTORC1-independent pathways, including MAPK signaling, YAP activation, and TRIM28 phosphorylation, which regulate transcription and ribosome biogenesis independently of the mTORC1 pathway.

Score breakdown, mechanism chain, raw evidence, ideal studies needed

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