NAC helps fat cells burn more energy and improves how the body handles sugar, which helps with energy levels and reduces cravings.
Scientific Claim
N-acetylcysteine upregulates thermogenic genes (UCP3, PGC1α) in adipose tissue, increasing mitochondrial activity and energy expenditure, while reducing hyperinsulinemia and improving glucose clearance.
Original Statement
“That same study also found that increased expression of thermogenic genes like uncoupling protein 3, PGC1 alpha, these are genes that are involved in mitochondrial activity and energy expenditure all getting increased. We have a serious metabolic change occurring. So fat cells weren't just storing less fat, they were burning more and this connects directly to insulin. Okay, in that study, obesity associated hyperinsulinemia dropped from about 8.3 micrograms per liter to 1.1 with simple NAC supplementation. So postmeal glucose spikes were lower. Glucose cleared faster, which matters because insulin resistance doesn't just block fat loss. It creates fatigue. It increases cravings. It's giving you unstable energy. It's messing with your brain. It's making your dog lose hair.”
Context Details
Domain
nutrition
Population
animal
Subject
N-acetylcysteine (NAC)
Action
upregulates
Target
thermogenic genes (UCP3, PGC1α), increasing mitochondrial activity and energy expenditure, while reducing hyperinsulinemia and improving glucose clearance
Intervention Details
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders