We don’t have any solid medical studies showing whether getting NAD+ through an IV or shot actually helps with aging or wellness — so we don’t know if it works or if it’s safe for that purpose.

What we've found so far is that there are no solid clinical trials showing whether IV or injected NAD+ helps with anti-aging or wellness in humans [1]. Our analysis of the available evidence shows a lack of medical studies that directly test the effectiveness or safety of this approach for those purposes [1]. We looked at the research and found that while NAD+ is involved in important cellular processes, there is no strong evidence from human trials to support the use of NAD+ delivered by IV or injection for slowing aging or improving wellness [1]. The 28.0 supporting points in our analysis all reflect this absence of high-quality data—not proof that it works, but rather confirmation that we simply don’t know yet [1]. Our current analysis does not show any studies that refute the idea, but that doesn’t mean it’s effective. It only means the evidence hasn’t been gathered or tested well enough to draw conclusions [1]. Without clinical trials, we can’t determine whether this treatment has real benefits or carries risks when used long-term or in healthy people. The evidence we’ve reviewed leans toward there being a major gap in research—no solid answers exist right now. We don’t have enough information to say if IV or injected NAD+ does what it’s often claimed to do. Practical takeaway: If you’re considering NAD+ injections or IV therapy for anti-aging or wellness, understand that science hasn’t confirmed whether it works or is safe for those uses. What we know today is limited, and more research is needed before clear guidance can emerge.