The Claim
In wild-type mice, serum TSH levels display a circadian rhythm under constant darkness with peak concentration at circadian time 12.5 (CT12.5), and a biphasic pattern under light-dark conditions with higher levels at zeitgeber times 8 and 16 (ZT8 and ZT16) compared to ZT24, whereas serum T4 levels do not exhibit significant 24-hour variation in these mice.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In normal mice, the hormone TSH goes up and down during the day depending on light conditions — peaking at certain times in the dark and showing two peaks when there's a regular light-dark cycle — but another hormone, T4, stays pretty steady all day long.
See the scientific wording
Serum TSH levels in wild-type mice exhibit a circadian rhythm under constant darkness with peak concentration around CT12.5, and a biphasic pattern under light-dark conditions with higher levels at ZT8 and ZT16 compared to ZT24, while T4 levels do not show significant 24-hour variation in wild-type mice.
What the research says
1 studyStudy: The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice
The study shows that in normal mice, TSH levels go up at night and T4 stays steady throughout the day, which matches what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.