The Claim

In obese adults, a 10-day protein-sparing modified fast delivered via nasogastric tube is associated with a significant reduction in appetite as measured by the Visual Analog Scale, with suppression maintained at 30 days.

Source: Feasibility of protein-sparing modified fast by tube (ProMoFasT) in obesity treatment: a phase II pilot trial on clinical safety and efficacy (appetite control, body composition, muscular strength, metabolic pattern, pulmonary function test)

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
45score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Obese adults who receive a 10-day protein-sparing modified fast through a nasogastric tube experience a significant reduction in appetite that lasts for at least 30 days, as measured by the Visual Analog Scale.

See the scientific wording

In obese adults, a 10-day protein-sparing modified fast delivered via nasogastric tube is associated with a significant reduction in appetite, as measured by the Visual Analog Scale, with suppression maintained at 30 days, suggesting a sustained anorexigenic effect potentially linked to ketosis or enteral feeding mechanics.

Why this might work

When the body runs out of carbohydrates, it starts burning fat for fuel and produces ketones. These ketones enter the brain and turn off hunger signals while turning on fullness signals. At the same time, food delivered directly into the stomach through a tube triggers the gut to release chemicals that tell the brain to stop feeling hungry. Together, these two effects shut down appetite quickly and keep it suppressed for weeks.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Feasibility of protein-sparing modified fast by tube (ProMoFasT) in obesity treatment: a phase II pilot trial on clinical safety and efficacy (appetite control, body composition, muscular strength, metabolic pattern, pulmonary function test)

    Obese people who got their food through a tube for 10 days, then ate less for 20 more days, reported feeling much less hungry—and that low hunger lasted the whole 30 days. The study confirms this effect.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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