People who are obese and have type 2 diabetes who carry a specific gene change (ApoB deletion) tend to have more body inflammation, less ability to fight off cell damage, and worse cholesterol levels—all together making their health worse than expected.

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Pro

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Evidence from Studies

Supporting (1)

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Community contributions welcome

37

Deletion allele of Apo B gene is associated with higher inflammation, oxidative stress and dyslipidemia in obese type 2 diabetic patients: an analytical cross-sectional study

Cross-Sectional Study

Human

2022 Mar 22

This study found that obese diabetic patients with a specific gene variant (ApoB deletion) have more inflammation, less ability to fight cell damage, and worse cholesterol levels than those without the variant — exactly what the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Deletion allele of Apo B gene is associated with higher inflammation, oxidative stress and dyslipidemia in obese type 2 diabetic patients: an analytical cross-sectional study

Score: 37

DOI: 10.1186/s12902-022-00991-y

Similar Assertions

People who are obese and have type 2 diabetes and carry a specific version of the ApoB gene tend to have more body inflammation, less ability to fight off cell damage, and worse cholesterol levels than those without this gene version.

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If you have type 2 diabetes and are overweight, having a certain gene variant (ApoB deletion) might raise your 'bad' cholesterol and worsen your cholesterol balance—but if you're not overweight, this gene doesn't seem to affect your cholesterol at all.

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If you're overweight and have type 2 diabetes, having a specific genetic variation called the ApoB deletion allele might mean your body is under more oxidative stress—like your fats are getting damaged more easily—than if you had the same gene but weren't overweight.

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88%

If you're overweight and have type 2 diabetes, and you have a specific gene variation called ApoB deletion, your body might have less of a natural antioxidant shield—making it harder to fight off cell damage—compared to others with the same gene who aren't overweight.

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