Why some diabetic people with extra weight have more heart risks
Deletion allele of Apo B gene is associated with higher inflammation, oxidative stress and dyslipidemia in obese type 2 diabetic patients: an analytical cross-sectional study
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
The ApoB deletion allele had no negative effect on lipid or oxidative stress markers in non-obese diabetics — meaning the gene alone is harmless.
Most genetic studies assume risk alleles are always risky. This shows a gene can be completely benign unless paired with a specific environmental trigger (obesity).
Practical Takeaways
If you have type 2 diabetes and are obese, losing even 5–10% of body weight may neutralize the harmful effects of the ApoB deletion allele.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
The ApoB deletion allele had no negative effect on lipid or oxidative stress markers in non-obese diabetics — meaning the gene alone is harmless.
Most genetic studies assume risk alleles are always risky. This shows a gene can be completely benign unless paired with a specific environmental trigger (obesity).
Practical Takeaways
If you have type 2 diabetes and are obese, losing even 5–10% of body weight may neutralize the harmful effects of the ApoB deletion allele.
Publication
Journal
BMC Endocrine Disorders
Year
2022
Authors
Nasim Mokhtary, S. N. Mousavi, G. Sotoudeh, M. Qorbani, Maryam Dehghani, F. Koohdani
Related Content
Claims (6)
When the inner lining of your arteries gets damaged, bad cholesterol (LDL) slips in and gets oxidized, which tricks your body into sending in immune cells that create fatty buildup—leading to clogged arteries.
People who are obese and have type 2 diabetes and carry a specific version of the ApoB gene tend to have more body inflammation, less ability to fight off cell damage, and worse cholesterol levels than those without this gene version.
People who are obese and have type 2 diabetes who carry a specific gene change (ApoB deletion) tend to have more body inflammation, less ability to fight off cell damage, and worse cholesterol levels—all together making their health worse than expected.
If you're overweight and have type 2 diabetes, having a specific genetic variation called the ApoB deletion allele might mean your body is under more oxidative stress—like your fats are getting damaged more easily—than if you had the same gene but weren't overweight.
If you're overweight and have type 2 diabetes, and you have a specific gene variation called ApoB deletion, your body might have less of a natural antioxidant shield—making it harder to fight off cell damage—compared to others with the same gene who aren't overweight.