Older adults had lower levels of a key antioxidant called glutathione, and this was linked to having more cell damage, worse energy production in cells, more inflammation, worse blood sugar control, worse blood vessel function, worse walking ability, bigger waistlines, and higher blood pressure compared to younger adults.
Scientific Claim
In older adults, glutathione deficiency was associated with higher levels of oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, impaired physical function, increased waist circumference, and systolic blood pressure compared to young adults.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study describes a comparison between older and young adults without claiming causation. The language 'had' is appropriate for describing observed differences between groups.
Source Excerpt
“Compared to YA, OA had GSH deficiency, OxS, mitochondrial dysfunction (with defective molecular regulation), inflammation, endothelial dysfunction, IR, multiple aging hallmarks, impaired physical function, increased waist circumference, and systolic blood pressure.”