A vitamin supplement for older adults to feel younger

Original Title

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

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Summary

Older adults took a special vitamin mix (GlyNAC) for 4 months and saw big improvements in their body's health markers.

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Surprising Findings

GlyNAC improved mitochondrial function by increasing fat burning by 78% while reducing glucose oxidation by 65%, which is counterintuitive since most people think of mitochondria as 'energy factories' that should burn more glucose.

Most people assume better metabolism means burning more glucose, but this shows the body was actually becoming more efficient at using fat for energy, which is typically associated with younger, healthier metabolism.

Practical Takeaways

Older adults with obesity might consider discussing GlyNAC supplementation with their doctor, as it improved multiple aging markers without weight loss.

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Publication

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences

Year

2022

Authors

Premranjan Kumar, Chun Liu, J. Suliburk, Jean W. Hsu, R. Muthupillai, F. Jahoor, C. Minard, G. Taffet, R. Sekhar

Open Access
99 citations