Taking GlyNAC for 16 weeks helps older adults with obesity make more of their body's main antioxidant in muscles and blood, bringing it up to levels normally seen in younger people.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 significantly increased skeletal muscle glutathione concentrations by 164% and red blood cell total glutathione by 225%, restoring levels to those seen in young adults.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of glutathione levels before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Source Excerpt

“Only GlyNAC supplementation in OA resulted in significantly improved (a) GSH concentrations by 121% after 2-weeks, and by 164% after 16-weeks to levels not different from YA-0w”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The study measured muscle and RBC glutathione levels before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant increases in both muscle and RBC glutathione after 16 weeks of GlyNAC supplementation, with levels reaching those of young adults. Placebo group showed no improvement.

Score

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Supported

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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Taking GlyNAC for 16 weeks helped older adults have higher levels of glutathione, a key antioxidant, compared to before they started taking it.

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