Taking GlyNAC for 16 weeks helps older adults with obesity reduce belly fat and lower blood pressure, but doesn't significantly change overall weight or body mass index.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 reduced waist circumference by 3% and systolic blood pressure by 6%, with no significant changes in body weight or BMI.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of body composition and blood pressure before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Source Excerpt

“GlyNAC supplementation for 16-weeks decreased waist circumference, and a trend toward decreasing both body weight and BMI”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The study measured waist circumference and blood pressure before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant reductions in waist circumference and systolic blood pressure after 16 weeks of GlyNAC supplementation. Body weight and BMI showed only trends toward reduction but were not statistically significant.

Score

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Supported

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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