Taking GlyNAC for 16 weeks significantly reduces markers of oxidative damage in older adults with obesity, bringing them down to levels normally seen in younger people.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 reduced plasma thiobarbituric acid reducing substances (TBARS) by 72% and plasma F2-isoprostane by 72%, bringing oxidative stress markers to levels comparable to young adults.

Original Statement

“Only GlyNAC supplementation in OA significantly lowered these markers after 2-weeks (TBARS 42% lower; F2-I 44% lower) and 16-weeks (TBARS 72% lower; F2-I 72% lower) to levels not different from YA-0w”

From study:Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of oxidative stress markers before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Evidence from Studies

Supporting (1)

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Human

2023 Jan 26

Contradicting (0)

No contradicting evidence found

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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Taking GlyNAC for 16 weeks helps older adults with obesity reduce belly fat and lower blood pressure, but doesn't significantly change overall weight or body mass index.

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Taking GlyNAC for 16 weeks helps older adults with obesity reduce DNA damage in their blood and muscles, which could help protect against cellular aging and disease.

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Taking GlyNAC for 16 weeks helps older adults with obesity make more of their body's main antioxidant in muscles and blood, bringing it up to levels normally seen in younger people.

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Taking GlyNAC for 16 weeks helps older adults with obesity burn fat more efficiently in their mitochondria and use less glucose for energy, bringing their metabolism closer to that of younger people.

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Taking GlyNAC for 16 weeks significantly improves insulin sensitivity in older adults with obesity, bringing it back to levels normally seen in younger people.

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