Taking GlyNAC for 16 weeks significantly reduces markers of oxidative damage in older adults with obesity, bringing them down to levels normally seen in younger people.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 reduced plasma thiobarbituric acid reducing substances (TBARS) by 72% and plasma F2-isoprostane by 72%, bringing oxidative stress markers to levels comparable to young adults.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of oxidative stress markers before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Source Excerpt

“Only GlyNAC supplementation in OA significantly lowered these markers after 2-weeks (TBARS 42% lower; F2-I 44% lower) and 16-weeks (TBARS 72% lower; F2-I 72% lower) to levels not different from YA-0w”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The study measured plasma TBARS and F2-isoprostane (oxidative stress markers) before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant reductions in both markers after 16 weeks of GlyNAC supplementation, with levels reaching those of young adults. Placebo group showed no improvement.

Score

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Supported

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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