Taking GlyNAC for 16 weeks helps older adults with obesity reduce DNA damage in their blood and muscles, which could help protect against cellular aging and disease.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 reduced plasma 8-hydroxy-2-deoxyguanosine by 73% and muscle pH2AX expression by 45%, indicating reduced DNA damage.

Original Statement

“Only GlyNAC supplementation in OA lowered plasma 8-OHdG by 57% after 2-weeks, and by 73% after 16-weeks, and significantly lowered muscle pH2AX after 16-weeks”

From study:Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of DNA damage markers before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Evidence from Studies

Supporting (1)

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Human

2023 Jan 26

Contradicting (0)

No contradicting evidence found

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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