Taking GlyNAC for 16 weeks helps older adults with obesity walk faster and have stronger hands, bringing their physical abilities closer to those of younger people.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 improved gait speed by 19% and increased grip strength by 14% in the dominant hand, restoring physical function to levels seen in young adults.

Original Statement

“Only GlyNAC supplementation increased gait speed in OAG-16w to levels not different from YA-0w, increased upper and lower extremity muscle strength, with a trend toward increasing 6-minute walk distance”

From study:Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of physical function before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Evidence from Studies

Supporting (1)

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Human

2023 Jan 26

Contradicting (0)

No contradicting evidence found

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

Similar Assertions

Taking GlyNAC for 16 weeks helps older adults with obesity reduce belly fat and lower blood pressure, but doesn't significantly change overall weight or body mass index.

90%

Taking GlyNAC for 16 weeks helps older adults with obesity reduce DNA damage in their blood and muscles, which could help protect against cellular aging and disease.

87%

Taking GlyNAC for 16 weeks helped older adults walk faster, have stronger muscles, and walk farther in 6 minutes compared to before they started taking it.

87%

Taking GlyNAC for 16 weeks significantly improves insulin sensitivity in older adults with obesity, bringing it back to levels normally seen in younger people.

87%

Taking GlyNAC for 16 weeks helps older adults with obesity make more of their body's main antioxidant in muscles and blood, bringing it up to levels normally seen in younger people.

86%