Taking GlyNAC for 16 weeks helps older adults with obesity improve blood vessel health by reducing markers of inflammation in blood vessels, bringing them back to levels normally seen in younger people.
Scientific Claim
GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 improved endothelial function by reducing soluble intercellular adhesion molecule-1 by 57% and soluble vascular cell adhesion molecule-1 by 44%, restoring levels to those seen in young adults.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a randomized controlled trial with direct measurements of endothelial function markers before and after intervention. The study design supports causal claims about the specific outcome measured in this population.
Source Excerpt
“Only GlyNAC supplementation improved these markers after 2-weeks (sICAM1 27% lower; sVCAM1 21% lower), and after 16-weeks (sICAM1 57% lower; sVCAM1 44% lower) to values not different from YA-0w”
Evidence from Studies
Supporting Evidence (1)
The study measured sICAM1 and sVCAM1 (markers of endothelial function) before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant improvements in both markers after 16 weeks of GlyNAC supplementation, with levels reaching those of young adults. Placebo group showed no improvement.