Taking GlyNAC for 16 weeks significantly improves insulin sensitivity in older adults with obesity, bringing it back to levels normally seen in younger people.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 improved insulin resistance by 64% as measured by HOMA-IR, restoring levels to those seen in young adults.

Original Statement

“GlyNAC supplementation in OA significantly lowered IR and fasting insulin concentrations after 2-weeks (HOMA-IR 31%; fasting insulin 34%), and after 16-weeks (HOMA-IR 64%; fasting insulin 65%) to values not different from YA-0w”

From study:Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of insulin resistance before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Evidence from Studies

Supporting (1)

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Human

2023 Jan 26

Contradicting (0)

No contradicting evidence found

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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Taking GlyNAC for 16 weeks helps older adults with obesity reduce belly fat and lower blood pressure, but doesn't significantly change overall weight or body mass index.

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Taking GlyNAC for 16 weeks helps older adults with obesity reduce DNA damage in their blood and muscles, which could help protect against cellular aging and disease.

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Taking GlyNAC for 16 weeks helps older adults with obesity burn fat more efficiently in their mitochondria and use less glucose for energy, bringing their metabolism closer to that of younger people.

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Taking GlyNAC for 16 weeks helps older adults with obesity walk faster and have stronger hands, bringing their physical abilities closer to those of younger people.

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