Taking GlyNAC for 16 weeks significantly improves insulin sensitivity in older adults with obesity, bringing it back to levels normally seen in younger people.

Scientific Claim

GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 improved insulin resistance by 64% as measured by HOMA-IR, restoring levels to those seen in young adults.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

This is a randomized controlled trial with direct measurements of insulin resistance before and after intervention. The study design supports causal claims about the specific outcome measured in this population.

Source Excerpt

“GlyNAC supplementation in OA significantly lowered IR and fasting insulin concentrations after 2-weeks (HOMA-IR 31%; fasting insulin 34%), and after 16-weeks (HOMA-IR 64%; fasting insulin 65%) to values not different from YA-0w”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The study measured HOMA-IR (a marker of insulin resistance) before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant improvements in insulin resistance after 16 weeks of GlyNAC supplementation, with levels reaching those of young adults. Placebo group showed no improvement.

Score

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

RCT

Supported

Source Study

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.

Score: 36

DOI: 10.1093/gerona/glac135

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