Taking GlyNAC for 16 weeks helps older adults with obesity burn fat more efficiently in their mitochondria and use less glucose for energy, bringing their metabolism closer to that of younger people.
Scientific Claim
GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 improved mitochondrial fatty-acid oxidation by 78% and reduced mitochondrial glucose oxidation by 65%, restoring these metabolic parameters to levels seen in young adults.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a randomized controlled trial with direct measurements of mitochondrial function before and after intervention. The study design supports causal claims about the specific outcome measured in this population.
Source Excerpt
“Only GlyNAC supplementation in OA improved RQ, MFO, and MGO after 2-weeks (RQ 4% lower; MFO 29% higher; and MGO 32% lower) and 16-weeks (RQ 9% lower; MFO 78% higher; and MGO 65% lower) to values not different from YA-0w”
Evidence from Studies
Supporting Evidence (1)
The study measured mitochondrial fatty-acid oxidation (MFO) and mitochondrial glucose oxidation (MGO) before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant improvements in both parameters after 16 weeks of GlyNAC supplementation, with levels reaching those of young adults. Placebo group showed no improvement.