Taking GlyNAC for 16 weeks helped older adults' cells better use fat for energy and improved the proteins that control energy production in cells compared to before they started taking it.
Scientific Claim
GlyNAC supplementation for 16 weeks in older adults was associated with improvements in mitochondrial fatty-acid oxidation and molecular regulators of energy metabolism compared to baseline measurements.
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study claims 'improved/corrected these defects' which implies causation. However, the study design has unclear blinding, making it a Level 2b evidence (cohort-level) rather than RCT-level evidence. Therefore, 'improved' should be replaced with 'associated with improvements' to reflect the association rather than causation.
Source Excerpt
“Participants were studied before, after 2-weeks, and after 16-weeks of supplementation to assess GSH concentrations, OxS, MFO, molecular regulators of energy metabolism, inflammation, endothelial function, IR, aging hallmarks, gait speed, muscle strength, 6-minute walk test, body composition, and blood pressure.”