Taking GlyNAC for 16 weeks helped older adults have better levels of antioxidants, less cell damage, better energy production in cells, less inflammation, better blood sugar control, better blood vessel function, better walking ability, and lower blood pressure compared to before they started taking it.
Scientific Claim
GlyNAC supplementation for 16 weeks in older adults was associated with improvements in glutathione levels, oxidative stress markers, mitochondrial function, inflammation, insulin resistance, endothelial function, physical performance metrics, body composition, and blood pressure compared to baseline measurements.
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study claims 'improved/corrected these defects' and 'reverses multiple age-associated abnormalities' which implies causation. However, the study design has unclear blinding, making it a Level 2b evidence (cohort-level) rather than RCT-level evidence. Therefore, 'improved' should be replaced with 'associated with improvements' to reflect the association rather than causation.
Source Excerpt
“Compared to YA, OA had GSH deficiency, OxS, mitochondrial dysfunction (with defective molecular regulation), inflammation, endothelial dysfunction, IR, multiple aging hallmarks, impaired physical function, increased waist circumference, and systolic blood pressure. GlyNAC (and not placebo) supplementation in OA improved/corrected these defects.”