In people aged 65 and older, being more socially active is linked to lower levels of a marker of inflammation called C-reactive protein, and higher levels of this marker are linked to less social...
Mechanism
Synthesis from 1 study
When older people spend time with others, their stress levels go down, which lowers inflammation in their body. When inflammation is high, they feel tired and less like going out, so they socialize less — creating a cycle where being social helps reduce inflammation, and less inflammation helps...
Most probable mechanism
When older adults spend time with others, their bodies produce less of the stress hormone cortisol, which in turn reduces the release of inflammatory chemicals into the blood. When there’s more inflammation in the blood, it makes people feel tired or unwell, so they’re less likely to want to go out and be social.
Social engagement reduces activation of the hypothalamic-pituitary-adrenal axis, lowering circulating cortisol levels
Lower cortisol levels reduce stimulation of immune cells that produce C-reactive protein
Reduced C-reactive protein levels correlate with improved energy and physical well-being, supporting continued social activity
Elevated C-reactive protein is associated with fatigue, malaise, and reduced motivation for social interaction
Less supported by current evidence, but not ruled out
Being around others may activate a nerve that calms the body’s immune system, reducing the release of inflammatory chemicals.
Social interaction increases parasympathetic nervous system activity, particularly vagal tone
Increased vagal tone inhibits nuclear factor kappa B signaling in macrophages, reducing interleukin-6 production
Lower interleukin-6 reduces hepatic synthesis of C-reactive protein
Evidence from Studies
Supporting (1)
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Contradicting (0)
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