Older adults with type 2 diabetes live, on average, 2.15 fewer years without disability compared to older adults without diabetes, even when accounting for other health factors like BMI and heart...
Mechanism
Synthesis from 1 study
High blood sugar over years slowly damages the nerves and tiny blood vessels in the legs, making it harder to feel your feet and move well. This leads to stumbling, weakness, and trouble doing everyday things — so people with diabetes lose their independence sooner.
Most probable mechanism
High blood sugar over time damages nerves and blood vessels, especially in the legs and feet. This makes it harder to feel the ground, move smoothly, or stay balanced, and also slows healing when injuries happen. As a result, older adults with diabetes lose their ability to walk or do daily tasks sooner than those without diabetes.
Chronic elevated blood glucose levels cause glycation of proteins in peripheral nerves, impairing signal transmission to and from muscles
Microvascular damage reduces blood flow to skeletal muscle and skin, limiting oxygen delivery and impairing tissue repair
Neuropathy and reduced perfusion combine to decrease muscle strength, proprioception, and balance control
Declining motor function increases risk of falls, mobility limitations, and loss of independence
Evidence from Studies
Supporting (1)
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Contradicting (0)
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