The Claim

Administration of 4-Phenylbutyrate to female UM-HET3 mice resulted in a statistically significant 2% reduction in median lifespan (p=0.01) and a 6% reduction in 90th percentile survival (p=0.06), indicating a potentially harmful effect on longevity.

Source: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

What the research says

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Supports
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Challenges
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These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
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In plain English

A compound called 4-Phenylbutyrate made female mice die slightly sooner - their lifespan was shortened by about 2%, and the oldest surviving mice died about 6% earlier than expected.

See the scientific wording

4-Phenylbutyrate significantly reduced female UM-HET3 mouse lifespan by 2% (p=0.01) and reduced 90th percentile survival by 6% (p=0.06), representing a potential harmful effect

Score breakdown, mechanism chain, raw evidence, ideal studies needed

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