The Claim
Basal concentrations of serum testosterone, free testosterone, cortisol, and growth hormone do not change over a six-month period of hypertrophic resistance training in trained men, irrespective of whether 2-minute or 5-minute rest periods are used between sets.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In men who regularly lift weights to build muscle, resting levels of testosterone, free testosterone, cortisol, and growth hormone stay the same after six months of training, whether they rest for 2 minutes or 5 minutes between sets.
See the scientific wording
Basal (resting) concentrations of serum testosterone, free testosterone, cortisol, and growth hormone remain unchanged over six months of hypertrophic resistance training regardless of whether 2-minute or 5-minute rest periods are used between sets in trained men.
Even when muscles get bigger from heavy lifting, the body keeps its resting hormone levels steady because it constantly checks and adjusts hormone production to avoid too much or too little, no matter how long you rest between sets.
What the research says
1 studyEven if trained men rest for 2 or 5 minutes between leg workouts for six months, their resting hormone levels like testosterone and cortisol don’t change — the body stays balanced despite getting stronger.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.