Men who are overweight or obese tend to have higher levels of homocysteine in their blood after an overnight fast compared to men with normal weight. Eating meals high in fat or carbohydrates causes homocysteine levels to rise further in the hours after eating.

In men with overweight or obesity, eating a single meal high in fat leads to higher levels of triglycerides and homocysteine in the blood after eating than eating a meal with the same number of calories but high in carbohydrates.

Taking omega-3 supplements by themselves may slightly lower a substance in your blood called homocysteine, which some doctors think might be linked to heart health — and this effect happens even if you're not taking folic acid or B vitamins too.