Pancreatic cells from people with type 2 diabetes have less MOTS-c gene activity than healthy cells.
Scientific Claim
mtRNR1 (MOTS-c) mRNA expression levels are lower in pancreatic β-cells of type 2 diabetes patients compared to healthy controls.
Original Statement
“By analyzing two publicly available datasets, we found that T2D male and female β-cells exhibited lower mRNA expression levels of MOTS-c (mtRNR1) compared with the healthy controls (Fig. 3a).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim uses 'are lower' which describes an association observed in the data without implying causation. Public dataset analysis supports this correlational claim.
Evidence from Studies
Supporting (1)
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes