The Claim

Consumption of trans-fatty acids is associated with elevated serum alanine aminotransferase levels compared to diets rich in palmitic or oleic acid in individuals with MASLD, across both murine and human models.

Source: GPAM upregulation enhances hepatic fat deposition and reduces visceral adipose tissue in response to trans-fatty acids

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
40score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Diets high in trans-fatty acids are linked to higher levels of alanine aminotransferase in the blood, a marker of liver cell damage, compared to diets high in palmitic or oleic acid in people and mice with MASLD.

See the scientific wording

Trans-fatty acid consumption is associated with higher serum alanine aminotransferase levels, indicating potential liver cell injury, compared to diets rich in palmitic or oleic acid in both mice and humans with MASLD.

Why this might work

When trans fats enter the liver, they turn on a gene that makes an enzyme that builds fat molecules. This enzyme forces the liver to store more fat inside its cells, which damages the cells and causes a marker of liver injury to leak into the blood.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: GPAM upregulation enhances hepatic fat deposition and reduces visceral adipose tissue in response to trans-fatty acids

    This study found that mice and people who ate trans fats had higher levels of a liver damage marker (ALT) than those who ate other fats like palm or olive oil, meaning trans fats may hurt the liver more.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.