Taking diabetes drugs called GLP-1 receptor agonists might slightly improve mood in people, whether or not they have diabetes, based on depression score changes in studies.

People with Type 2 diabetes who take GLP-1 drugs like semaglutide or liraglutide might feel a little less depressed, even if that’s not why they’re taking the medicine.

People with type 2 diabetes who take GLP-1 drugs like Ozempic might feel a little better emotionally, but the mood boost is small and doesn’t show up in every study.

Older Black male veterans with diabetes, fatty liver, and depression who take GLP-1 drugs like semaglutide have slightly lower depression scores than those on SGLT2 drugs, but the difference isn’t big enough to be sure it’s not just by chance.

Some diabetes drugs called GLP-1 agonists might help with depression symptoms, based on a few studies — but the results aren't clear-cut and more research is needed.

Some diabetes drugs called GLP-1 RAs might help with depression in animals — most lab studies saw fewer signs of depression, and scientists think it’s because these drugs change brain inflammation, brain cell connections, and brain chemicals.