People with Type 2 diabetes who take GLP-1 drugs like semaglutide or liraglutide might feel a little less depressed, even if that’s not why they’re taking the medicine.

Taking diabetes drugs called GLP-1 receptor agonists might slightly improve mood in people, whether or not they have diabetes, based on depression score changes in studies.

People with type 2 diabetes who take GLP-1 drugs like Ozempic might feel a little better emotionally, but the mood boost is small and doesn’t show up in every study.

Older Black male veterans with diabetes, fatty liver, and depression who take GLP-1 drugs like semaglutide have slightly lower depression scores than those on SGLT2 drugs, but the difference isn’t big enough to be sure it’s not just by chance.

People with type 2 diabetes or obesity who take GLP-1 drugs like semaglutide might be less likely to develop depression or anxiety.

Some diabetes drugs called GLP-1 RAs might help with depression in animals — most lab studies saw fewer signs of depression, and scientists think it’s because these drugs change brain inflammation, brain cell connections, and brain chemicals.