Taking a weekly semaglutide shot (2.4 mg) for about a year helps people with extra weight feel more physically capable and improves their overall quality of life—more than a dummy pill would.

Taking a weekly semaglutide shot (2.4 mg) for about a year and a half can help lower blood pressure, blood sugar, bad cholesterol, and body-wide inflammation in adults with extra weight but no diabetes—better than a placebo.

Among adults with obesity taking semaglutide for a year, those without type 2 diabetes lost an average of 16.9% of their body weight, while those with type 2 diabetes lost an average of 9.9%.

When adults with obesity take a drug called semaglutide 2.4 mg for about 1.5 years, nearly 9 out of 10 lose at least 5% of their body weight — compared to only about 1 in 3 to half of those taking a sugar pill or another drug, meaning semaglutide works better for weight loss in most people.

For adults who aren't diabetic but carry extra weight, a weekly injection of semaglutide (2.4 mg) plus healthy lifestyle changes led to nearly 15% weight loss over a year and a half—way more than lifestyle changes alone.

People with obesity and knee arthritis who took a weekly semaglutide shot for over a year felt physically better than those who took a dummy shot — their ability to do everyday physical activities improved more, by about twice as much.