When older people do strength training, those who get the biggest muscle gains also tend to have a much bigger rise in a protein called c-Myc—some see it jump 250%, while others only see a 50% rise.

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Pro

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Against

Evidence from Studies

Supporting (1)

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Community contributions welcome

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Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.

Cohort Study

Human

2016 Apr 15

The study found that older adults who got much stronger after weight training also had a big spike in a protein called c-Myc — exactly as the claim says. Those who didn’t grow much had only a small spike.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.

Score: 46

DOI: 10.1152/ajpendo.00486.2015

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When older people do strength training and their muscles grow a lot, the muscle cells add more nuclei—and those who grow the most gain about 32% more nuclei than those who don’t grow much.

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Lifting weights helps people build bigger, stronger muscles, probably because it makes their muscles produce more protein and release helpful signaling molecules that help them grow and work better.

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