The Claim
A 1-standard deviation increase in genetically predicted body mass index (BMI) is associated with a 49% higher risk of coronary artery disease, with 66% (95% CI: 42% to 91%) of this association mediated through systolic blood pressure, diabetes, lipid traits, and smoking, where diabetes and blood pressure account for the largest proportions of the mediated effect.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
People with a genetically higher body mass index have a 49% higher risk of coronary artery disease, and two-thirds of this increased risk is explained by higher blood pressure, diabetes, abnormal lipid levels, and smoking, with blood pressure and diabetes contributing the most.
See the scientific wording
A 1-standard deviation increase in genetically predicted body mass index (BMI) is associated with a 49% higher risk of coronary artery disease, of which 66% (95% CI: 42% to 91%) is mediated through systolic blood pressure, diabetes, lipid traits, and smoking, with diabetes and blood pressure accounting for the largest proportions of this effect.
Extra fat tissue releases substances that raise blood pressure and make the body less able to use insulin, which damages blood vessels and causes plaque to build up in the heart arteries.
What the research says
1 studyPeople who are genetically more likely to have higher body weight have a 49% higher risk of heart disease, and about two-thirds of that risk comes from high blood pressure and diabetes — the study proves this exactly.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.