The Claim
Serum levels of interleukin-6 (IL-6) and trimethylamine-N-oxide (TMAO) are significantly higher in individuals with coronary artery disease than in those without, and higher concentrations of these biomarkers are independently associated with increased severity of coronary artery stenosis as measured by the Gensini score.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
People with coronary artery disease have higher levels of two blood markers, interleukin-6 and TMAO, than people without the disease. Higher levels of these markers are linked to more severe narrowing of the coronary arteries.
See the scientific wording
Serum levels of interleukin-6 (IL-6) and trimethylamine-N-oxide (TMAO) are significantly elevated in individuals with coronary artery disease compared to those without, and higher concentrations of these biomarkers are independently associated with greater coronary artery stenosis severity as measured by the Gensini score, suggesting their potential utility as clinical indicators of disease burden.
Bad bacteria in the gut break down food into chemicals that enter the blood, triggering inflammation and damaging blood vessel walls. This causes plaque to build up inside heart arteries, making them narrower and reducing blood flow.
What the research says
1 studyPeople with heart artery disease had higher levels of two blood chemicals, IL-6 and TMAO, than those without it—and the higher these chemicals were, the more blocked their arteries were. This suggests doctors could use these chemicals to tell how bad someone’s heart disease is.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.