correlational
Analysis v1
Strong Support
People with rare harmful changes in the TP53 gene tend to live shorter lives, mostly because they’re much more likely to get certain cancers like breast or blood cancer.
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0
Evidence from Studies
Supporting (1)
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Community contributions welcome
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Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes
Cohort Study
Human
2025 Feb 28The study found that harmful rare changes in the TP53 gene are linked to shorter lives, mostly because of cancer, which supports the main idea of the claim.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.